Synephrine
CAS NO.: 94-07-5
Molecular Formula: C9H13NO2
Molecular Weight: 167.21
Source: Citrus aurantium extract
Active Ingredient: Synephrine
Specification: 6%–98% Synephrine (HPLC)
Appearance: White to off-white powder
Solubility: Water soluble
Test Method: HPLC
Extraction Method: Ethanol/Water
Particle Size: 80 mesh
Grade: Food grade / Pharmaceutical grade
Shelf Life: 24 months
Storage: Cool and dry place, avoid light
Packaging: 1 kg foil bag + 25 kg fiber drum
Description:
Synephrine is a naturally occurring protoalkaloid primarily derived from Citrus
aurantium extract and is widely recognized as one of the key active compounds
responsible for the biological activity of bitter orange. As a standardized
ingredient, Synephrine is commonly produced through controlled extraction and
purification processes to ensure consistent potency, purity, and stability.
High-quality Synephrine is typically standardized by HPLC, allowing precise
control of active content across different specifications ranging from low
concentration botanical extracts to high-purity Synephrine powders.
In the global nutraceutical market,
Synephrine has become a core ingredient in formulations targeting weight
management, metabolic support, and energy enhancement. Compared with
traditional stimulants, Synephrine from Citrus aurantium extract is often preferred
due to its relatively moderate pharmacological profile, offering functional
benefits without excessive central nervous system stimulation. This makes
Synephrine particularly suitable for combination formulas where balanced
performance is required.
From a formulation perspective, Synephrine
demonstrates good water solubility and compatibility with a wide range of
excipients, making it easy to incorporate into capsules, tablets, powders, and
functional beverages. In addition, Synephrine is frequently used alongside
other botanical ingredients such as green tea extract, caffeine, or capsaicin
to create synergistic effects in thermogenic and metabolic products. With
increasing demand for plant-derived active ingredients, Synephrine continues to
gain traction as a reliable and scalable solution for modern health product
development.
Function:
1. Supports fat metabolism: Synephrine promotes lipolysis by activating
specific adrenergic pathways, helping the body break down stored fat and
convert it into usable energy, making Synephrine a central component in weight
management formulations.
2. Enhances metabolic rate: Synephrine contributes to increased basal
metabolic activity, supporting calorie expenditure even at rest, which is
critical for long-term metabolic balance.
3. Promotes thermogenesis: Synephrine stimulates heat production in the
body, which can enhance fat oxidation and improve overall energy utilization
efficiency.
4. Provides energy support: Synephrine helps improve physical energy
levels and endurance, making it suitable for sports nutrition and active
lifestyle products.
5. Assists appetite regulation: Synephrine may influence
appetite-related pathways, helping to support reduced caloric intake in dietary
programs.
6. Mild adrenergic stimulation: Synephrine interacts selectively with
beta-3 adrenergic receptors, offering targeted metabolic effects with
relatively lower cardiovascular stimulation compared to stronger stimulants.
7. Supports lipid metabolism balance: Synephrine plays a role in
regulating lipid utilization and may contribute to maintaining healthy body
composition.
8. Enhances synergistic effects: Synephrine is often combined with
other active ingredients to amplify thermogenic and metabolic responses in
complex formulations.
Application:
1. Dietary supplements: Synephrine is widely used in capsules, tablets,
and powder blends designed for weight management, fat burning, and energy
support, making Synephrine one of the most common ingredients in this category.
2. Functional beverages: Synephrine can be incorporated into
ready-to-drink beverages, energy drinks, and metabolic support formulations due
to its solubility and stability.
3. Sports nutrition products: Synephrine is commonly included in
pre-workout, fat burner, and performance-enhancing formulations to support
endurance, focus, and calorie utilization.
4. Nutritional powders: Synephrine is used in meal replacement powders
and protein blends targeting weight control and metabolic optimization.
5. Herbal formulations: As a key component of Citrus aurantium extract,
Synephrine is widely applied in botanical blends and traditional herbal
products.
6. Pharmaceutical and health products: Standardized Synephrine is used
in formulations requiring strict quality control, precise dosing, and
consistent efficacy.
7. Compound formulations: Synephrine is frequently combined with
ingredients such as caffeine, green tea extract, L-carnitine, and capsaicin to
create multi-functional metabolic products.
Synephrine — FAQ Section
1. What is Synephrine?
Synephrine is a naturally occurring alkaloid extracted from Citrus aurantium
extract and widely used in dietary supplements for metabolism and energy
support.
2. What is the source of Synephrine?
Synephrine is primarily derived from the immature fruit of Citrus aurantium,
also known as bitter orange.
3. What specifications of Synephrine are
available?
Synephrine is commonly available in 6%, 10%, 20%, 30%, 50%, 90%, 95%, and 98%
Synephrine (HPLC).
4. How is Synephrine tested?
Synephrine content is typically analyzed by HPLC to ensure accuracy, purity,
and consistency.
5. What does high-purity Synephrine
mean?
High-purity Synephrine refers to standardized extracts with higher active
content, such as 95% or 98% Synephrine.
6. Is Synephrine water soluble?
Yes, Synephrine is water soluble, making it suitable for beverages and liquid
formulations.
7. What are the main benefits of
Synephrine?
Synephrine is mainly used to support metabolism, fat burning, and energy
enhancement.
8. How does Synephrine support weight
management?
Synephrine promotes thermogenesis and fat metabolism, helping the body utilize
stored fat as energy.
9. Is Synephrine a stimulant?
Synephrine has mild adrenergic activity, offering moderate stimulation compared
to stronger compounds.
10. Can Synephrine be combined with
other ingredients?
Yes, Synephrine is often combined with caffeine, green tea extract, or
L-carnitine for enhanced effects.
11. What industries use Synephrine?
Synephrine is widely used in nutraceuticals, sports nutrition, functional
foods, and pharmaceuticals.
12. What forms of products contain
Synephrine?
Synephrine is used in capsules, tablets, powders, and functional beverages.
13. What is the appearance of
Synephrine?
Synephrine appears as a white to off-white fine powder.
14. What is the shelf life of
Synephrine?
Synephrine typically has a shelf life of 24 months when stored properly.
15. How should Synephrine be stored?
Synephrine should be stored in a cool, dry place away from light and moisture.
16. What is the extraction method of
Synephrine?
Synephrine is extracted using ethanol and water, followed by purification and
crystallization.
17. Is Synephrine suitable for
beverages?
Yes, due to its solubility, Synephrine is suitable for functional drinks and
energy beverages.
18. What grade of Synephrine is
available?
Synephrine is available in food grade, pharmaceutical grade, and dietary
supplement grade.
19. What is the CAS number of
Synephrine?
The CAS number of Synephrine is 94-07-5.
20. Does Synephrine contain heavy
metals?
High-quality Synephrine complies with strict limits on heavy metals such as
lead, arsenic, cadmium, and mercury.
21. What packaging is used for
Synephrine?
Synephrine is typically packed in 1 kg foil bags and 25 kg fiber drums.
22. Can Synephrine be used in sports
nutrition?
Yes, Synephrine is commonly used in pre-workout and fat-burning formulations.
23. What makes Synephrine popular in the
market?
Synephrine is valued for its natural origin, stable supply, and functional
benefits in metabolism support.
24. Is Synephrine suitable for herbal
formulations?
Yes, Synephrine as part of Citrus aurantium extract is widely used in botanical
blends.
25. What is the particle size of
Synephrine powder?
Synephrine is typically processed to 80–100 mesh for better mixing and
formulation.
26. Does Synephrine have good
compatibility in formulations?
Yes, Synephrine is compatible with a wide range of ingredients and excipients.
27. What quality documents are available
for Synephrine?
COA, MSDS, and TDS are available for Synephrine upon request.
28. Can Synephrine be customized?
Yes, specifications, particle size, and packaging of Synephrine can be
customized.
29. Is Synephrine suitable for global
export?
Yes, Synephrine is widely exported and complies with international quality
standards.
30. What is the minimum order quantity
for Synephrine?
MOQ for Synephrine varies depending on specification and packaging
requirements.
31. Is Synephrine stable in
formulations?
Yes, Synephrine shows good stability under normal storage and processing
conditions.
32. Why choose standardized Synephrine?
Standardized Synephrine ensures consistent potency, quality, and performance in
final products.
Looking for a reliable supplier of
Synephrine for beverage, cosmetic or sports nutrition formulations?
Request detailed specifications, COA, MSDS, bulk
pricing or a trial sample today. Our team offers professional technical support
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